Philip Ng

Philip Ng is an Associate Professor at Baylor College of Medicine in the Department of Molecular and Human Genetics. He also holds a position in the Program in Translational Biology & Molecular Medicine. His research specializes in gene therapy, particularly using helper-dependent adenoviral vectors (HDAd) for liver and lung diseases.

• BS, University of Toronto
• MS, University of Guelph
• PhD, University of Guelph
• Post-Doctoral Fellowship, McMaster University

Research Focus

Dr. Ng's laboratory develops HDAd vectors for gene therapy, which lack viral genes to improve safety and efficacy. Key areas include:

• Liver-directed therapies for hemophilia, Crigler-Najjar syndrome, and cardiovascular disease
• Lung-directed therapies for cystic fibrosis
• Vector capsid modifications to enhance hepatocyte transduction
• Immune response investigations to refine host-vector interactions
• Gene editing in human-induced pluripotent stem cells (iPSCs) without double-strand breaks

The lab pioneers clinical manufacturing under cGMP and innovative delivery methods like balloon occlusion catheters for targeted therapy in large animals.

Contact

Email: png@bcm.edu