Philip J. S. Stork

Philip J. S. Stork, M.D., is a Senior Scientist at the Vollum Institute with a joint appointment in the Department of Cell, Developmental and Cancer Biology at Oregon Health & Science University's School of Medicine. He earned his B.S. from Harvard University (1977), M.S. from Stanford University (1978), and M.D. from Columbia University (1984). His training includes a residency in Pathology at Harvard Medical School and a fellowship at Tufts-New England Medical Center. Dr. Stork began his academic career as an Assistant Professor at Tufts University (1988) before joining the Vollum Institute in 1990, where he progressed to Scientist (1997) and Senior Scientist (2005).

His research employs molecular and biochemical approaches to investigate signal transduction mechanisms, focusing on how hormones and growth factors regulate cellular responses through pathways involving:

• Small G proteins (Ras/Rap1)
• MAP kinase cascades (ERK/B-Raf)
• cAMP-dependent protein kinase signaling
• Membrane domain organization
• Oncogene-induced senescence

Dr. Stork's publications demonstrate consistent focus on kinase signaling dynamics, membrane protein trafficking, and metabolic regulation in cancer and neuronal contexts. His laboratory develops innovative techniques including fluorescent biosensors and high-throughput single-particle tracking to study real-time cellular processes. He served on the Editorial Board of Molecular Cell Biology (2008-2020).

The Stork Laboratory maintains active investigations into fundamental signal transduction principles, particularly the spatiotemporal regulation of signaling cascades and their pathological disruptions.