معرفی
Peter W. Abel is a Professor and Chair of the Department of Pharmacology and Neuroscience at Creighton University School of Medicine. His research focuses on G protein-coupled receptors (GPCRs) and their signaling mechanisms in diseases like asthma, pulmonary hypertension, and cancers.
- University: Creighton University
- School: School of Medicine
- Department: Department of Pharmacology and Neuroscience
- Academic Rank: Professor
Research Interests: Dr. Abel investigates adrenergic receptors, calcitonin gene-related peptide (CGRP) receptors, and regulatory mechanisms in smooth muscle and cancer cells. His work explores:
- GPCR signaling pathways in airway and vascular dysfunction
- Role of RGS2 in airway hyperresponsiveness and remodeling
- Epigenetic regulation of P-Rex1 and RGS2 in cancer metastasis
- Development of irreversible peptide antagonists for CGRP receptors
Recent Publication Trends: His studies span asthma (RGS2 repression, P-Rex1 upregulation), prostate and breast cancer (epigenetic changes, PKCε pathways), and chemical synthesis of receptor ligands. Collaborative work includes cytokine networks in corticosteroid resistance.
Lab Members: Current researchers include PhD candidate Cameron Kieffer, undergraduate Julia Chowdhury, and medical students David Maas and Nate Rosol. Collaborators: Dr. Charles Bockman (Assistant Professor) and Dr. David Smith (Associate Professor).
