معرفی
Jason Cao serves as a Research Fellow in the Drug Discovery Biology department within Monash University's Faculty of Pharmacy and Pharmaceutical Sciences. His work focuses on structural mechanisms of G protein-coupled receptors (GPCRs), particularly amylin and calcitonin receptors using cryo-electron microscopy.
His research interests center on GPCR structural pharmacology, with specialization in peptide hormone receptors. Using cutting-edge cryo-EM techniques, he investigates conformational dynamics of class B1 GPCRs, receptor selectivity mechanisms, and peptide-receptor interactions. His work provides critical insights for developing therapeutics targeting metabolic disorders and migraines.
Dr. Cao's publication record demonstrates significant contributions to structural biology, with high-impact papers in Science and Nature Chemical Biology analyzing CGRP and amylin receptor complexes. His research shows consistent focus on membrane protein dynamics and receptor activation mechanisms.
- The 2023 Mollie Holman Award
- The 2024 Anders Early Career Award
His collaborative research involves major international networks, with extensive co-authorship including prominent researchers like Arthur Christopoulos, Denise Wootten, and Patrick Sexton. Current work emphasizes cryo-EM structural determination of receptor-G protein complexes and molecular basis of peptide agonist selectivity.