معرفی
Peter Pioli is an Assistant Professor in the Department of Biochemistry, Microbiology & Immunology at the University of Saskatchewan's College of Medicine. His research focuses on antibody-secreting cells (plasma cells), hematopoiesis aging, and their roles in immune dysfunction and leukemia development. Dr. Pioli holds a PhD from the University of Utah (2015), an MSc from UC Irvine (2010), and a BSc from the University of Wisconsin-Parkside (2006).
Research Interests:
- Regulation of plasma cell biology across lifespan
- Age-related changes in hematopoietic stem cell function
- Interactions between antibody-secreting cells and bone marrow microenvironment
- Mechanisms linking plasma cells to myeloid leukemia progression
- Sex differences in plasma cell development
Recent work demonstrates plasma cells' dual roles in immunity and hematopoietic regulation, with particular attention to their pro-myeloid effects in aged bone marrow. His lab uses single-cell transcriptomics and in vivo signaling blockade to identify regulatory pathways.
Lab activities focus on developing strategies to modulate plasma cell behavior to improve host health outcomes. Current projects explore interferon signaling in thymus-resident plasma cells and hepatocyte-marrow cross-talk in lymphopoiesis.
