معرفی
Peter J. Park is the BIG Program Director and Professor of Biomedical Informatics at Harvard Medical School. He leads a computational biology group affiliated with the Harvard Ludwig Center, Brain Somatic Mosaicism Network, 4D Nucleome Network, and Brigham and Women’s Hospital.
His research focuses on:
- Genome and epigenome analysis of somatic mutations
- Non-coding mutation roles in disease
- Mosaic mutations in neurodegeneration and cancer
- Single-cell sequencing for low-frequency variant detection
His lab develops computational tools like MuSiCal (mutational signatures), Chromoscope (SV visualization), and MosaicForecast (machine learning variant calling), with applications across cancer biology and neuroscience consortia.
حوزههای پژوهشی
Mutational processes in cancer and normal cellsComputational methods for genome and epigenome analysisSingle-cell genomicsSomatic mutations in neuronsNon-coding mutationsMosaic mutations in cancer and neurodegenerationStructural variation analysisIntratumoral heterogeneitySpatial transcriptomicsFetal hemoglobin repression mechanismsMicrofluidic sequencing assaysBioinformatics tool development
۰مقاله منتشرشده
