Peter Coote

Dr Peter Coote is a Lecturer at the School of Biology, University of St Andrews. His research focuses on antifungal mechanisms, antimicrobial resistance, and the development of novel treatments against fungal and bacterial pathogens. He employs cutting-edge techniques such as proteomics, genomics, and in vivo infection models like the Galleria mellonella larvae system. Key research areas include understanding the mode of action of antifungals, synergistic antibiotic combinations, and overcoming multidrug resistance in pathogens such as Pseudomonas aeruginosa and Staphylococcus aureus.

Coote’s work integrates functional genomics approaches, including DNA microarrays and deletion strain libraries, to identify genes and pathways involved in fungal resistance. His lab also investigates plant-derived compounds and antimicrobial peptides for their potential in combating drug-resistant infections. A significant portion of his research evaluates combination therapies to enhance antibiotic efficacy and reduce resistance development, with applications in both clinical and food safety contexts.

Publications highlight breakthroughs in repurposing existing drugs (e.g., zidovudine), synergistic antibiotic pairings, and the use of efflux pump inhibitors. His studies leverage in vivo models to assess treatment efficacy and safety, particularly in complex infections. While no formal advisees are listed, his research teams actively collaborate on projects related to microbial pathogenesis and drug discovery.