معرفی
Per-Johan Jakobsson is a Professor and Research Group Leader at Karolinska Institutet in the Division of Rheumatology, Department of Medicine, Solna. He leads the Translational Inflammation Research group, focusing on prostaglandin pathways (e.g., mPGES-1 inhibitors), lipid metabolomics, and biomarkers in rheumatic and autoimmune diseases.
His research explores the arachidonic acid cascade, proteomics, cytokine profiling, and collaborations with Guangdong Provincial Hospital of Chinese Medicine for traditional medicine-based drug discovery. Key interests include:
- Molecular mechanisms of inflammation in rheumatology and cancer
- Development of mPGES-1 inhibitors for therapeutic intervention
- Lipid mediator pathways in autoimmune disorders
- Integrative approaches combining proteomics and metabolomics
Recent publications (2021-2025) emphasize prostaglandin biology, autoantibody roles in systemic lupus and myositis, tumor microenvironment modulation, and cardiovascular implications of anti-inflammatory therapies. Trends include biomarker discovery and targeted inhibition of inflammatory enzymes.
Jakobsson mentors PhD students and postdocs, overseeing projects on prostaglandin signaling, autoimmunity, and cancer biology. His team utilizes advanced analytical techniques (e.g., proteomics, lipidomics) and collaborates globally to validate therapeutic targets.
