معرفی
Peisong Ma serves as an Associate Professor in the Department of Medicine at Thomas Jefferson University's Sidney Kimmel Medical College, specializing in platelet biology and cardiovascular research. His work bridges fundamental mechanisms of hemostasis with translational applications for thrombotic disorders.
Dr. Ma's laboratory investigates GPCR-mediated platelet activation through three primary research thrusts: (1) characterizing a common GRK5 polymorphism affecting 5 million Americans that elevates cardiovascular risk for pulmonary embolism and stroke; (2) mapping regulatory networks controlling platelet activation via genome-wide CRISPR-Cas9 screening; and (3) defining GRK roles in megakaryopoiesis and thrombopoiesis to develop targeted therapies for platelet disorders. The lab employs cutting-edge methodologies including CRISPR-Cas9 genome editing, induced pluripotent stem cells, vascular injury models, and biochemical analyses to dissect signaling pathways.
Publication trends reveal strong emphasis on molecular mechanisms of platelet reactivity, with recent work spanning nanoparticle-based antithrombotics, sex-specific platelet regulation, nuclear receptor signaling in hypercholesterolemia, and constitutive translation in platelets. These studies consistently target therapeutic innovation while maintaining bleeding safety profiles.
Dr. Ma leads an active research group supported by the Cardeza Foundation for Hematologic Research, with dedicated laboratory facilities focused on translational hematology. The team maintains strong institutional connections through the Sidney Kimmel Medical College and collaborates extensively on vascular biology and cardiovascular disease mechanisms.
