معرفی
Pedro Lowenstein is a Professor at the University of Michigan, holding appointments in the Department of Neurosurgery and Cell and Developmental Biology. He serves as Program Director of MM Neurosurgery and Assistant Chair of Neurosurgery. Lowenstein is a member of the AI and Digital Health Innovation, Rogel Cancer Center, and Center for Cell Plasticity and Organ Design.
- Education
- MD, University of Buenos Aires School of Medicine (1981)
- PhD, University of Buenos Aires (1984)
Research Interests: Lowenstein's work focuses on three main areas:
- Tumor Self-organization: Molecular and physical mechanisms of glioma growth, invasion, and microenvironmental interactions, particularly H3.3-G34R and IDH1 mutations.
- Adaptive Immunity: T-cell and NK-cell interactions with gliomas, including immunological synapse formation and mechanisms of immune evasion.
- Clinical Translation: Development of combined cytotoxic/immune-stimulatory gene therapy (Ad-hCMV-TK/Flt3L) for glioblastoma, leading to FDA-approved Phase I trials (NCT01811992).
Scientific Trends: Recent publications emphasize epigenetic reprogramming, liquid crystal tumor modeling, and AI-driven diagnostics. Collaborative work with Maria G. Castro spans in vivo models and clinical trial implementation.
Key Grants include NIH funding for neuro-immune mechanisms, American Brain Tumor Association projects on tumor microenvironment, and Alex's Lemonade Stand support for pediatric glioma gene therapy.
