Pawel Kiela

Pawel Kiela, DVM, PhD, is a Professor in the Department of Pediatrics at the University of Arizona. His research focuses on the interplay between gastrointestinal disorders, inflammation, and cancer, with a particular emphasis on pediatric populations. His work explores mechanisms linking gut microbiota dysbiosis, immune responses, and disease progression in conditions such as inflammatory bowel disease (IBD), colorectal cancer, and PANDAS. Recent studies highlight the role of ion transporters (e.g., NHE3, NCX3), microbiome dynamics, and targeted therapies in modulating disease outcomes.

Key research interests include understanding how genetic variants (e.g., NTHL1) contribute to tumor initiation, investigating the therapeutic potential of miRNA-based therapies and pro-drugs, and analyzing the impact of environmental factors (e.g., diet, antibiotics) on gut health. His studies often utilize mouse models to dissect pathogenic mechanisms and test novel interventions.

Dr. Kiela’s publications reflect a multidisciplinary approach, combining molecular biology, immunology, and clinical trials. Notably, his work demonstrates how gut microbiota transplantation can induce colitis in germ-free mice, underscoring the microbiome’s role in disease. He has also explored the role of microglia in neuroinflammatory conditions and the efficacy of stabilized chlorine dioxide in reducing mucositis.

No scientific awards are explicitly mentioned in the provided texts. His research is supported by collaborations across pediatrics, immunology, and oncology, though specific grants or funding sources are not detailed here.