Luis Sifuentes-Dominguez

Dr. Luis Sifuentes-Dominguez is a Research Fellow at the University of Texas Southwestern Medical Center, affiliated with the School of Medicine and the Department of Pediatrics, specializing in Pediatric Gastroenterology. His work focuses on inflammatory bowel disease (IBD), leveraging genomic and proteomic approaches to uncover molecular mechanisms underlying early-onset IBD. He collaborates closely with Dr. Ezra Burstein on projects involving endosomal sorting pathways, gut microbiota interactions, and cancer biology.

His research interests span IBD pathogenesis, molecular signaling pathways (e.g., Notch and WASH complexes), and the role of Paneth cells in tumorigenesis. Key contributions include identifying novel genes linked to IBD and demonstrating how microbiota editing can reduce carcinogenesis in colitis models. His work has been supported by an NIH-sponsored Career Development Award.

Publications highlight advancements in gut microbiota modulation, SCGN deficiency effects on colitis, and mechanistic studies of secretagogin-mediated exocytosis. His findings have implications for developing targeted therapies for gastrointestinal disorders and cancer.