Pavlos Vlachos

Pavlos Vlachos is a Professor of Mechanical Engineering at Purdue University, affiliated with both the Department of Mechanical Engineering and the Biomedical Engineering program. He holds an office in the MANN building and is part of the Moveable Dream Hire Committee. His research focuses on fluid dynamics, biomedical engineering, and cardiovascular systems, with applications in medical imaging, drug delivery systems, and computational modeling.

His work combines experimental and computational methods to study intracardiac flow in congenital heart diseases, subcutaneous drug delivery mechanisms, and novel echocardiographic biomarkers for sepsis and heart failure. He has developed advanced imaging techniques like 4D flow MRI reconstruction and Doppler velocity analysis tools for clinical diagnostics. His projects often bridge engineering and medicine, addressing challenges in pediatric cardiology, nanomedicine, and biomaterials.

Key contributions include computational models for autoinjector performance, non-invasive cardiac flow assessment, and machine learning approaches for echocardiogram analysis. He actively engages in educational initiatives integrating virtual and physical labs for fluid mechanics education, emphasizing hands-on learning through open projects and data-driven experiments.

His research portfolio spans over 50 peer-reviewed articles between 2022-2025, with a focus on translational biomedical engineering. Collaborations involve multi-disciplinary teams from cardiology, bioengineering, and materials science. Current interests include optimizing subcutaneous injection systems, predicting sepsis outcomes via hemodynamic indices, and improving diagnostic accuracy through automated image segmentation.