Pavel Sumazin

Pavel Sumazin is a Professor in the Department of Pediatrics at Baylor College of Medicine. He holds additional affiliations with the Dan L Duncan Comprehensive Cancer Center and the Quantitative and Computational Biosciences program at Baylor.

His research focuses on computational and molecular analyses of cancer genomics, particularly in pediatric tumors. Major areas include non-coding RNA regulation, gene expression networks, and functional interpretation of genomic variants in cis and trans contexts. His work bridges computational biology with experimental validation to identify cancer driver genes and therapeutic targets.

Recent publications highlight his expertise in lncRNA-target interactions, radiosensitivity prediction in pancreatic cancer, and innovative CAR T-cell therapies for solid tumors. His laboratory develops computational models for bulk RNA-Seq deconvolution and investigates metabolic vulnerabilities in neuroblastoma and leukemia.

Prof. Sumazin's work has contributed to understanding tumor heterogeneity in hepatoblastoma, mechanisms of chemotherapy resistance in pediatric AML, and safety concerns in CRISPR/Cas9 gene therapy. His methodologies integrate machine learning with experimental validation for clinical applications.