معرفی
Paul Worley, MD is a Professor of Neuroscience at the Solomon H. Snyder Department of Neuroscience within the Johns Hopkins University School of Medicine. His research focuses on cellular and molecular mechanisms underlying synaptic plasticity, memory consolidation, and neurodegenerative diseases such as Alzheimer's and schizophrenia. He leads a lab investigating immediate early genes like Arc and NPTX2, which regulate synaptic strength and neural circuit dynamics.
Research Interests:
- Neural circuits and synaptic plasticity
- Molecular basis of memory formation
- Role of dendritic protein synthesis in learning
- Neurodegenerative disease mechanisms
Publications highlight his work on Arc's role in AMPA receptor trafficking, NPTX2 as a biomarker for cognitive decline, and molecular pathways linking neuronal activity to myelination. His lab employs techniques including in vivo imaging, electrophysiology, and CSF biomarker analysis.
Former students and lab members hold positions at institutions like Stanford, UCSF, and Emory University, reflecting his impact on training future neuroscientists.
