معرفی
Paul Stemmer is a Professor at Wayne State University's Eugene Applebaum College of Pharmacy and Health Sciences, specifically within the Institute of Environmental Health Sciences. His research focuses on understanding cellular regulation mechanisms through studying calcineurin phosphatases, immunosuppressive drugs, and proteomic analysis techniques.
Research Focus:
- Immunosuppression: Investigating the mechanisms of action of immunosuppressive drugs like Cyclosporin-A and Tacrolimus, which inhibit calcineurin phosphatase activity and made organ transplantation possible.
- Calcineurin Phosphatase Regulation: Studying the integration of five regulatory mechanisms (calmodulin, calcineurin-B, redox state, targeting proteins, and enzyme structure) using site-directed mutagenesis to create novel proteins.
- Proteomic Analysis: Employing two-dimensional chromatography and mass spectrometry to profile proteomes and examine protein modifications that affect enzyme function.
Contact Information:
- Email: pmstemmer@wayne.edu
- Office Phone: (313) 577-6536
- Fax: (313) 577-0082
- Address: Institute of Environmental Health Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201
Teaching Activities:
Professor Stemmer teaches multiple courses including Functional Genomics and Systems Biology, Pharmacy Seminar, Principles of Toxicology, and Advanced Topics in Pharmacology across different academic terms from 2023-2025.
Research Trends:
His recent publications demonstrate a strong focus on proteomics applications in toxicology, neurodegeneration, and environmental health, with particular emphasis on biomarker discovery for drug-induced toxicity, neurotoxic mechanisms of environmental chemicals, and multi-omics approaches to understanding disease processes.
