معرفی
Martha S. Cyert, the Dr. Nancy Chang Professor and Chair of the Department of Biology at Stanford University's School of Humanities and Sciences, is a leading biochemist renowned for her work on calcineurin signaling networks. Recognized as a 2024 ASBMB Fellow, her research spans from yeast genetics to human proteomics, focusing on Ca²⁺-dependent signal transduction and phosphatase substrate recognition.
- Current roles: Department Chair (2020-present), Bio-X Member, Cardiovascular Institute Faculty Fellow
- Education: PhD in Genetics (UCSF 1988), Postdoc in Biochemistry (UC Berkeley 1992)
Her research reveals calcineurin's conserved functions across species, including:
- Discovery of novel signaling microdomains at centrosomes/nuclear pore complexes
- Mechanisms of immunosuppressant drugs (cyclosporine A, FK506)
- Dynamic palmitoylation in CNAβ1 isoform localization and activity
- Identification of SLiM-dependent phosphatase interactions via MRBLE-pep technology
Recent publications (2022-2024) demonstrate calcineurin's roles in:
- Phosphatidylinositol 4-kinase complex regulation at plasma membranes
- Palmitoylation-dependent targeting to Golgi apparatus
- Nuclear transport control through NPC phosphorylation
- Evolution of kinase-phosphatase signaling modules
Awarded:
- Stanford Biosciences Excellence in Mentoring (2015)
- Gabilan Fellow (2014-present)
- Ford University Fellow in Undergraduate Education (2012-present)
She directs educational initiatives including:
- Innovative undergraduate p53 research curriculum
- Summer transition program for underrepresented students
- NIH-funded graduate training program (2009-2019)
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