Paul J. Cullen

Paul J. Cullen, PhD, is a Professor in the Department of Biological Sciences at the University at Buffalo, College of Arts and Sciences. He has been recognized with the Distinguished Postdoctoral Mentor Award (2021-22), Milton Plesur Excellence in Teaching Award, and UB Exceptional Scholar — Sustained Achievement Award. Cullen serves as Director of Graduate Studies, emphasizing mentorship and academic development.

• Education: PhD in Biology, Washington University in St. Louis; BA in Biological Sciences, University of Illinois.

Cullen’s research focuses on signal transduction pathways, particularly the Mitogen-Activated Protein Kinase (MAPK) pathways in budding yeast (Saccharomyces cerevisiae). His work investigates how cells sense environmental changes and relay signals via Cdc42-dependent MAPK networks to regulate cell polarity, differentiation, and stress response. Key studies include the role of mucin-type glycoproteins (e.g., Msb2) in MAPK activation, protein degradation mechanisms preserving signaling fidelity, and cross-pathway interactions causing disease when dysregulated. His lab employs genetic, biochemical, and bioinformatic approaches to dissect these processes.

Recent publications highlight his team’s discoveries in MAPK pathway regulation through SEA domain analysis, gene-environment interactions, and chaperone-mediated protein turnover. These studies provide insights into fungal pathogenesis and eukaryotic signaling conservation.

Scientific Awards:

• Distinguished Postdoctoral Mentor Award (2021-22)
• Milton Plesur Excellence in Teaching Award
• UB Exceptional Scholar — Sustained Achievement Award

Cullen’s mentorship extends to postdoctoral scholars like Beatriz Gonzalez, who attributes her academic persistence to his guidance. His lab’s collaborative environment prioritizes career development and scientific passion, particularly for underrepresented researchers.