Paul Dark

Paul Dark is Professor of Critical Care Medicine at the University of Manchester and Honorary NHS Consultant at Northern Care Alliance NHS Foundation Trust. An NIHR Senior Investigator, his research program focuses on molecular diagnostics for sepsis/severe infections and developing point-of-care technologies to optimize antimicrobial use. He co-leads NIHR Manchester BRC's respiratory infections sub-theme and the NIHR HealthTech Research Centre in Emergency and Acute Care.

Major research areas include:

• Sepsis biomarker validation and clinical implementation
• COVID-19 therapeutic trials and genetic architecture
• Antimicrobial stewardship in critical care
• Trauma and emergency response systems

Publications demonstrate leadership in large-scale clinical trials including RECOVERY-RS, REMAP-CAP, and ADAPT-Sepsis, with consistent focus on improving outcomes in critical illness through evidence-based interventions. Recent work emphasizes pandemic response, immunomodulatory therapies, and diagnostic innovation.