معرفی
Pasko Rakic is the Dorys McConnell Duberg Professor of Neuroscience and Professor of Neurology at Yale School of Medicine, with affiliations to the Interdepartmental Neuroscience Program, Kavli Institute for Neuroscience, Wu Tsai Institute, and Yale Combined Program in the Biological and Biomedical Sciences. Holding a PhD (1969) and MD (1959) from Belgrade University, his research focuses on human and primate brain development.
- Research Themes: Developmental neurobiology, neuronal proliferation/migration, synaptic connectivity, epigenetic regulation, and primate brain evolution
- Methodologies: Organotypic culture, viral transduction, cell tracing, and transcriptomic analysis of embryonic human and primate tissues
His work challenges classical models of cortical development by identifying 'predecessor' cortical stem cells in human embryonic telencephalon and exploring their role in species-specific neurogenesis. Recent studies examine calcium signaling in prefrontal neurons and collaborative projects on Alzheimer's disease models in macaques.
Scientific Collaborators:
- Alvaro Duque (11 publications)
- Juan Arellano (9 publications)
- Yury Morozov (5 publications)
- Christopher van Dyck (3 publications)
- Dibyadeep Datta (3 publications)
- Michael Schwartz (3 publications)
He has contributed to understanding cortical disorders through studies on HM's brain, neural stem cell fate, and developmental gene expression patterns. His lab's work has implications for neuro-psychiatric disorders and human cognitive evolution.
