Paris Margaritis

Paris Margaritis, DPhil, is an Investigator at the CHOP Research Institute within the Department of Pediatrics and Division of Hematology. He leads the Margaritis Laboratory, focusing on coagulation disorders, particularly hemophilia, using biochemical, molecular, and in vivo methodologies to study pro- and anti-coagulant reactions.

• Email: margaritis@chop.edu

The Margaritis Lab developed a groundbreaking model involving enhanced FVIIa expression via gene transfer, achieving phenotypic correction in hemophilia models. They also engineered species-specific reagents for monitoring hemostatic effects and investigate molecular interactions between FVIIa and its binding partners, with implications for FVIIa-based therapeutics.

Scientific Awards:

• Bayer Award (2017) for advancing hemophilia research

His work spans gene therapy, protein engineering, and translational strategies for coagulation defects, leveraging in vitro and in vivo techniques to visualize real-time FVIIa reactions. The lab’s research includes viral transduction, hemostatic endpoints, and therapeutic design for hemophilia treatments.