Alessio Branchini

Alessio Branchini is an Associate Professor in the Department of Life Sciences and Biotechnology at the University of Ferrara. His research focuses on protein engineering, molecular mechanisms, and coagulation factors with particular emphasis on hemophilia and related blood disorders.

Dr. Branchini's research interests span protein engineering, molecular mechanisms of coagulation factors, fusion protein technology, and ribosome readthrough. He investigates how genetic mutations affect coagulation proteins, particularly factor IX in hemophilia B, and develops molecular approaches to correct these defects. His work combines structural biology, molecular genetics, and therapeutic development to address bleeding disorders.

His publication record shows a strong focus on coagulation factors, particularly factor IX and VIII, with recent work exploring translational readthrough mechanisms, splice site corrections using engineered U1snRNAs, and CRISPR-based approaches to activate coagulation gene promoters. His research bridges basic molecular mechanisms with potential therapeutic applications for hemophilia and related disorders.

Dr. Branchini has published extensively in top hematology and molecular biology journals including Journal of Thrombosis and Haemostasis, where he has contributed numerous articles on coagulation factor mechanisms and therapeutic approaches. His collaborative work with researchers like Pinotti M, Bernardi F, and others demonstrates a strong research network focused on bleeding disorders.