معرفی
Pablo Guardado-Calvo is a researcher at the Institut Pasteur, affiliated with the Structural Biology of Infectious Diseases team. His work focuses on the structural and functional characterization of viral glycoproteins from hantaviruses and poxviruses, contributing to antiviral and vaccine development.
Research Interests: Dr. Guardado-Calvo's research lies at the intersection of structural biology and virology, with a focus on understanding host-pathogen interactions. His work investigates the molecular mechanisms of viral entry, neutralizing antibody responses, and antiviral resistance. Key areas include hantavirus glycoprotein structure, poxvirus neutralization determinants, and the role of host receptors like protocadherin-1 in viral infection. He employs techniques such as cryo-electron microscopy, protein engineering, and functional assays to dissect viral fusion and immune evasion mechanisms.
Publication Trends: Over the past two years, his publications have centered on high-consequence emerging viruses, particularly hantaviruses and poxviruses (including mpox). His work combines structural insights with translational applications, aiming to inform the design of broad-spectrum therapeutics and vaccines. A strong theme is the structural basis of antibody neutralization and small-molecule antiviral action.
- Scientific Contributions:
- Elucidated the structural basis of tecovirimat’s antiviral activity and resistance in poxviruses.
- Identified protocadherin-1 as a critical hantavirus entry receptor and demonstrated protective mutations.
- Characterized neutralizing epitopes on hantavirus glycoproteins for therapeutic antibody development.
- Contributed to understanding poxvirus surface antigens for subunit vaccine design.
Advising and Collaborations: Dr. Guardado-Calvo collaborates extensively with leading virology and immunology groups at the Institut Pasteur and internationally, including Olivier Schwartz’s laboratory. He contributes to multidisciplinary projects involving structural biology, virology, and immunology. While no formal advisees are listed, he mentors junior researchers within his team and participates in collaborative training environments.
Laboratory and Team: He is a key member of the Structural Biology of Infectious Diseases team at the Institut Pasteur, working in a highly collaborative environment that integrates structural bioinformatics, biophysics, and virology. The team leverages cutting-edge platforms including cryo-EM and high-containment facilities for working with dangerous pathogens.
