معرفی
Dr. P. Lynne Howell is a Senior Scientist at the Department of Biochemistry, affiliated with the University of Toronto. Her research focuses on microbial pathogenesis, structural biology, and biofilm formation, particularly in Pseudomonas aeruginosa. She has developed novel therapeutic strategies targeting bacterial and fungal infections using glycoside hydrolases and small-molecule modulators.
- Role: Senior Scientist, Professor
- Department: Biochemistry
- University: University of Toronto
Research Interests: Dr. Howell's lab investigates molecular mechanisms of biofilm formation, exopolysaccharide biosynthesis, and type IV pilus assembly in pathogenic microbes. They combine structural biology, biophysics, and microbiology to design therapies for chronic infections.
Scientific Awards:
- Canada Research Chair in Structural Biology (2013–2020)
- Canada Research Chair in Structural Biology (2006–2013)
- CIHR Investigator Research Award (2001–2006)
- SERC Studentship Research Award (1983–1986)
Students: She supervises graduate students including Natalie Bamford, Andreea Gheorghita, Lindsey Marmont, Matthew McCallum, Erum Razvi, and Greg Whitfield.
Labs & Teams: The Howell Lab collaborates with structural biology and microbiology groups, focusing on microbial biofilm therapeutics. They utilize advanced technologies like nuclear magnetic resonance and X-ray crystallography.
