P. Kent Langston

Dr. P. Kent Langston is an Assistant Professor of Pathology at Yale School of Medicine and a core member of the Yale Center for Research on Aging (Y-Age). His research program bridges immunology, metabolism, and muscle biology, with a focus on how exercise-induced inflammation regulates tissue adaptation and aging. The Langston Laboratory investigates cellular communication between immune cells and skeletal muscle, aiming to develop interventions for age-related frailty and chronic inflammation.

Education:

• Postdoctoral Fellow, Harvard Medical School (2025)
• Ph.D. in Immunometabolism, Harvard University (2019)
• B.S. (Honors) in Chemistry, Wake Forest University (2014)

His research examines how regulatory T cells and interferon signaling modulate mitochondrial function in muscle during exercise, with recent work revealing how immune cells protect tissue energetics during physical adaptation. Studies employ in vivo exercise models, single-cell genomics, and metabolic phenotyping to dissect inflammation-resolution pathways that enhance performance and healthspan.

Publications demonstrate consistent focus on immunometabolic crosstalk, with recent high-impact papers in Science Immunology and Cell Metabolism exploring T cell regulation of muscle/brown fat physiology. Work spans basic mechanisms of macrophage metabolism to translational studies in fibrosis and age-related decline.

Lab leadership includes mentorship through Yale's BBS program and recruitment of research staff. Current funding includes an NIA/NIH K22 award supporting investigations into exercise immunology during aging.