Oscar Fernandez-Capetillo

Oscar Fernandez-Capetillo is a Professor at the Karolinska Institutet and leads a research group at the Spanish National Cancer Research Centre (CNIO) in Madrid. His work spans multiple disciplines including DNA damage response, replication stress, neurodegenerative diseases (ALS, Huntington's), and drug development.

• Research focuses on phenotypic screening for disease treatments
• Expertise in genomic instability and cancer therapy
• Collaborates with SciLifeLab's PHENOTARGET program
• Recruited Myriam Barz (PhD Student) and Wout Magits (Postdoc)

Recent publications (2024-2019) reveal trends in:

• Antiviral drug discovery (macropinocytosis inhibitors)
• PPARγ activators for polyQ toxicity (Huntington's)
• RNA translation modulators for neurodegenerative diseases
• ATR/CDK1 regulation in DNA repair
• Genomic stress in cancer and aging
• Protein ubiquitination/SUMOylation at replication forks

Awards include:

• Cell's '40 under 40' list (2014)
• Swedish Research Council grant (2023)

His Haploid mouse project aims to create organisms with single chromosome sets for gene function studies, while recent work explores ALS treatment through RNA translation modulation and BRCA-deficient cancer chemoresistance mechanisms.