معرفی
Dr Oliver Pain is a Sir Henry Wellcome Postdoctoral Research Fellow at the Maurice Wohl Clinical Neuroscience Institute, King's College London. His research focuses on statistical genetics, genome-wide association studies (GWAS), and functional genomic annotations to understand psychiatric and neurological disorders. He specializes in developing tools like the GenoPred pipeline for polygenic scoring and improving genetic prediction across diverse populations. Pain holds a PhD in psychiatric genetics from Birkbeck, University of London, and has contributed to projects such as the AMBER consortium investigating antidepressant response mechanisms.
Education:
- BSc in Molecular Genetics (King's College London, 2010–2013)
- MSc in Genes, Environment, and Development (Social Genetic & Developmental Psychiatry, 2013–2014)
- PhD in Psychiatric Genetics (Birkbeck, University of London, 2014–2017)
Research Interests: Pain's work integrates genetic and genomic data to uncover disease mechanisms, with a focus on depression, ALS, and polygenic risk prediction. His tools enhance clinical utility of genetic data, including UPDOG for trans-ancestry polygenic scores and GenoPred for scalable polygenic analysis.
Publications: Over 30 peer-reviewed articles, emphasizing polygenic methodologies, GWAS, and translational applications in precision medicine. Recent work includes advancements in ALS diagnostics and antidepressant response prediction.
Awards:
- Sir Henry Wellcome Postdoctoral Research Fellowship (2021–present)
Grants & Projects:
- Wellcome Trust grant for stratifying patients using genetics (2021–2026)
- Alan Turing Institute project on ALS drug targets (2022)
Labs & Teams: Part of the Statistical Genetics Unit led by Prof. Cathryn Lewis and collaborates with international consortia like the Psychiatric Genomics Consortium.
