معرفی
Dr. Nir Kalisman is a Senior Lecturer in the Department of Biological Chemistry at The Hebrew University of Jerusalem's Silberman Institute of Life Sciences. His research focuses on structural biology of large protein complexes using cross-linking mass spectrometry (XL-MS) and computational modeling. He leads the Kalisman Lab, which pioneers methods to study protein interactions in systems like the SARS-CoV-2 proteins and neuronal synapses.
- PhD in Computer Science (Ben-Gurion University, 2008)
- Postdoc in Michael Levitt's Lab at Stanford University (2008–2013)
Research interests include XL-MS method development, integrative structural modeling, and low-resolution crystallography applications. Key projects involve:
- Deciphering architectures of SARS-CoV-2 proteins (Nsp1, Nsp2, Nucleocapsid)
- Protein complex studies in neurobiology and transcription
- Formaldehyde cross-linking chemistry analysis
Publications span structural biology innovations and protein interaction studies. Lab members include graduate students and specialists in mass spectrometry. Software contributions include tools for cross-link interpretation and sequence inference from crystallographic data.
