معرفی
Nikola Pavletich is a Professor at Memorial Sloan Kettering Cancer Center's Structural Biology Program. His research focuses on structural mechanisms of cancer-related pathways.
- Stephen and Barbara Friedman Chair
- HHMI Investigator
- Affiliated with Tri-Institutional PhD Program in Chemical Biology
Education:
- PhD in Biochemistry, Johns Hopkins University
Research Focus
Dr. Pavletich investigates structural biology of cancer pathways through:
- mTOR signaling in cell growth regulation
- Fanconi Anemia pathway for DNA repair
- Homologous recombination mechanisms
- ATR/ATM checkpoint kinases
- Structural characterization of kinase inhibitors
Scientific Contributions
Key achievements:
- National Academy of Sciences member
- First high-resolution mTOR structures (PDB: 4JSN, 4JSP, 4JSV)
- Elucidated rapamycin inhibition mechanism
- Discovered DNA clamp function of FAN1 complex
- Defined mTORC1 activation by RHEB
Lab Structure
His lab includes:
- Yehuda Goldgur - X-ray Crystallography Core Facility
- Haijuan Yang - Senior Research Scientist
- Multiple research fellows and technicians
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