معرفی
Nicolas Michalski is a Permanent Researcher and Principal Investigator at the Hearing Institute of the Institut Pasteur in Paris, France. He heads research projects focusing on the molecular and genetic basis of auditory system development and dysfunction, particularly within the central auditory pathways and auditory cortex.
His research interests lie at the intersection of developmental neurobiology, neurophysiology, and sensory systems, with a strong emphasis on understanding how genetic mutations lead to central auditory deficits beyond cochlear dysfunction. He investigates the roles of cadherin-related proteins (cdhr15, cdhr23) and genes like Vlgr1 (involved in Usher Syndrome type 2C) in neuronal migration, maturation, and circuit formation in the brain.
His recent publications, featured in top journals like Advanced Science and PNAS, reveal trends in using advanced molecular and genetic techniques—such as single-cell transcriptomics and mouse models—to map cochlear cell types, understand auditory hyperexcitability, and dissect synaptic mechanisms in hearing. This work paves the way for gene therapies and improved rehabilitation strategies for complex forms of deafness.
- Position: Permanent Researcher, PI
- Institution: Institut Pasteur
- Unit: Hearing Institute – Plasticity of Central Auditory Circuits
Scientific Awards:
None mentioned in the provided text.
Advising and Grants:
Michalski supervises several PhD students, indicating an active mentoring role in training the next generation of auditory scientists. He leads research projects such as the SEIZEAR project on audiogenic seizures, suggesting he secures and manages research funding, although specific grants are not listed.
Labs and Teams:
He is a core member and project leader within the 'Plasticity of Central Auditory Circuits' team at the Hearing Institute, Institut Pasteur. This team investigates the development and molecular physiology of the auditory cortex under both normal and pathological conditions.
