Nicodemi Mario

Nicodemi Mario is a Full Professor at the National Research Council of Italy (CNR), affiliated with the Institute for Superconductors, Innovative Materials, and Devices (SPIN) within the Department of Physical Sciences and Technologies of Matter. His research focuses on the intersection of physics and biology, particularly applying polymer physics to study chromatin architecture, 3D genome organization, and their roles in cellular processes such as viral infections, cancer, and developmental biology. He leads interdisciplinary projects combining computational modeling, experimental data analysis, and biophysical approaches to unravel the principles governing chromatin folding and nuclear organization.

His work emphasizes understanding how chromatin structure impacts gene regulation, with notable contributions to studying viral infection effects on genome architecture, the dynamics of chromatin loops under disease conditions, and the development of novel tools like Multiplex-GAM for chromatin contact mapping. Recent studies explore the interplay between chromatin topology and cellular differentiation, leveraging single-molecule and single-cell technologies.

Key research areas include polymer models of chromatin, phase separation mechanisms, and the role of structural variants in genomic disorders. His team collaborates widely, contributing to initiatives like the 4D Nucleome Project. Despite no listed awards, his publications reflect a high-impact trajectory in biophysics and molecular biology.