معرفی
Dr. Nicholas Matheson is a researcher at the University of Cambridge's Department of Medicine and a collaborator in the Cambridge Immunology Network. His work focuses on understanding how viruses like HIV and SARS-CoV-2 manipulate host immunometabolism through protein regulation and proteomic analysis.
Research Focus:
Using SILAC and TMT-based proteomics, Matheson investigates how HIV accessory proteins (Vpu, Nef) modulate cell surface nutrient transporters to alter metabolic flux in infected cells. His studies extend to SARS-CoV-2 research, including viral entry mechanisms, immune response heterogeneity, and Long Covid pathogenesis.
Collaborative Themes:
His work spans
- Host-pathogen interactions in T cells
- CRISPR-Cas9 functional genomics
- Immunometabolic regulation
- Extracellular vesicle biology
- Viral entry mechanisms (TMPRSS2, ACE2)
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