Neil Clipstone

Neil Clipstone, PhD, is an Associate Professor in the Department of Molecular Pharmacology & Neuroscience at Loyola University Chicago’s Stritch School of Medicine. His research focuses on the calcineurin/NFAT-signaling pathway’s role in cell growth, differentiation, and disease processes such as adipocyte development, osteoclastogenesis, and cancer. His work integrates in vitro molecular techniques, biochemical analyses, and in vivo transgenic approaches to dissect signaling mechanisms in diverse biological systems.

Key research directions include: (1) calcineurin/NFAT’s role in adipocyte differentiation and metabolic disorders like obesity and type-2 diabetes; (2) calcineurin/NFAT’s contribution to cell transformation and cancer development; and (3) signaling pathways modulating immune responses and bone remodeling. Dr. Clipstone’s lab employs advanced models such as transgenic mice and cell culture systems to explore these mechanisms.

His publications highlight discoveries in prostaglandin-mediated adipogenesis inhibition, NFATc1-driven cell transformation, and calcineurin’s regulation of osteoclastogenesis. Research methodologies emphasize calcium signaling dynamics, transcription factor activation, and autocrine signaling pathways. Current projects aim to bridge basic signaling insights to translational applications in metabolic and neoplastic diseases.

Dr. Clipstone’s academic contributions include over 30 peer-reviewed articles in journals like Journal of Cellular Biochemistry and Journal of Immunology. His work has advanced understanding of calcineurin’s multifaceted roles beyond traditional immune contexts, extending to metabolic and oncological research.