معرفی
Natalie Poulter serves as an Assistant Professor in the Institute of Cardiovascular Sciences at the University of Birmingham, where she leads cutting-edge research in platelet biology and thrombosis. Her work bridges basic science with translational applications, focusing on molecular mechanisms underlying hemostasis and pathological clotting.
Dr. Poulter's research interests center on platelet receptor biology, particularly glycoprotein VI (GPVI) and its role in thrombus formation. Her work explores structural organization of platelet aggregates, molecular mechanisms of bleeding disorders like Scott Syndrome, and development of novel anti-thrombotic therapies using nanobody technology. She employs advanced techniques including expansion microscopy, microfluidic models, and structural biology approaches to investigate platelet function under physiological flow conditions.
Her recent publications reveal a strong focus on translational applications, with multiple projects developing bispecific nanobodies targeting platelet receptors for therapeutic use. The research demonstrates consistent innovation in imaging technologies for characterizing platelet ultrastructure and genetic approaches to understanding rare bleeding disorders.
Dr. Poulter currently leads multiple significant research projects funded by the Medical Research Council and British Heart Foundation, including development of novel anti-thrombotic therapies and investigation of SLFN14's role in platelet biology. Her collaborative network spans multiple institutions and includes substantial industry partnerships focused on therapeutic development.
Her laboratory maintains active research programs in platelet structural biology, translational therapeutics, and genetic hemostasis disorders, utilizing state-of-the-art microfluidic models and advanced imaging techniques to study platelet-endothelial interactions under flow conditions.
