Mukesh Gautam

Mukesh Gautam serves as a Research Assistant Professor in the Department of Neurology at Northwestern University's Feinberg School of Medicine, specializing in neurodegenerative diseases with primary focus on amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegia (HSP), and primary lateral sclerosis (PLS).

His academic credentials include:

• PhD from University of Delhi (2013)

Dr. Gautam's research centers on upper motor neuron vulnerability mechanisms in ALS and related disorders, investigating mitochondrial dysfunction, TDP-43 pathology, and neuroinflammatory processes. His work integrates epigenetics and metabolomics to identify therapeutic targets for neuromuscular diseases, with emphasis on preserving motor neuron integrity through novel pharmacological approaches.

Recent publications reveal strong thematic continuity in ALS research, particularly exploring mitochondrial regulation and TDP-43 pathology across multiple models. His work demonstrates progression from basic mechanistic studies toward translational applications, including drug development (SBT-272, NU-9) and metabolomic biomarker discovery, often examining synergistic effects with existing ALS therapeutics.

Professional recognition includes:

• Upper Motor Neuron Achievement Award, North East ALS Alliance (2025)

No specific advising relationships or grant details were documented in available materials, though his collaborative work with the Ozdinler laboratory indicates active mentorship within research teams.

Dr. Gautam maintains significant institutional affiliations through Northwestern's Center for Human Immunobiology, Clinical and Translational Sciences Institute (NUCATS), and Simpson Querrey Institute for Epigenetics, facilitating interdisciplinary approaches to neurodegenerative disease research.