Mollie Meffert

Mollie Meffert is an Associate Professor in the Department of Neuroscience at the Johns Hopkins University School of Medicine. She leads a research laboratory focused on the molecular mechanisms of gene expression regulation in the nervous system, with implications in neurodevelopmental and neurological diseases.

Education:

• BS in Neuroscience, Stanford University
• MD/PhD in Neuroscience, Stanford University School of Medicine
• Postdoctoral Fellowship, California Institute of Technology (with Dr. David Baltimore)

Her research lies at the intersection of molecular neuroscience and RNA biology, emphasizing how RNA-binding proteins and non-coding RNAs coordinate gene programs in neurons. Her lab investigates how activity-dependent regulation of microRNAs (e.g., let-7) and proteins like Lin28 control synaptic growth, metabolism, and repair. These mechanisms are studied in the context of synaptic plasticity, development, and disease models such as Fragile X syndrome.

The recent publications reflect a strong focus on discovery-based sequencing methods, bioinformatics tools (e.g., SCRAP pipeline), and in vivo profiling of RNA interactions. Collectively, her work spans molecular diagnostics, computational biology, quantitative imaging, and genetic models, demonstrating a multidisciplinary approach to understanding gene regulation in health and disease.

Scientific Awards:

• March of Dimes Research Scholar
• Simons Foundation Autism Research Initiative Award
• PLU Rho Award
• Alfred P. Sloan Research Fellow Award
• Hamilton Smith Award for Innovative Science
• Sontag Foundation Distinguished Scientist Award
• Sontag Foundation Distinguished Alumni Award
• Eric C. Aker Award Endowment (Braude Foundation)

Dr. Meffert actively mentors graduate students and postdoctoral fellows. Her lab includes predoctoral trainees and undergraduate researchers. She is affiliated with multiple graduate training programs, including the Neuroscience Training Program, Biochemistry, Cellular and Molecular Biology, Pathobiology, Biological Chemistry, and the XDBio Cross-Disciplinary Program. Her research is supported by competitive grants and endowments, enabling sustained investigation into the regulation of neuronal gene expression.

The Meffert Lab employs a combination of molecular, biochemical, imaging, and computational techniques to uncover how gene programs are dynamically regulated in neurons. The lab's work contributes to understanding both normal brain function and the molecular basis of neurodevelopmental disorders.