Mitchell Guttman

Mitchell Guttman is a Professor of Biology at the California Institute of Technology (Caltech), where he leads the Guttman Lab. His research focuses on understanding how long non-coding RNAs (lncRNAs) regulate gene expression and nuclear organization. He holds a B.S. and M.S. from the University of Pennsylvania (2006) and a Ph.D. from MIT (2012). Before becoming a full Professor in 2019, he served as an Assistant Professor at Caltech and a Visiting Associate. His work has pioneered methods like SPRITE and ChIP-DIP to map 3D genome organization and RNA-protein interactions.

Education:

• B.S., University of Pennsylvania, 2006
• M.S., University of Pennsylvania, 2006
• Ph.D., Massachusetts Institute of Technology, 2012

His research investigates how lncRNAs coordinate proteins, localize to genomic targets, and shape nuclear architecture to control gene expression. Recent breakthroughs include discoveries about nuclear speckles' role in mRNA splicing efficiency and the development of technologies for multiplexed protein-DNA/RNA interaction mapping. His lab integrates experimental and computational approaches, emphasizing collaboration across disciplines.

Key Projects:

• SPRITe: Maps multi-way DNA-RNA-protein interactions in 3D
• ChIP-DIP: Identifies hundreds of proteins binding DNA simultaneously
• SPIDR: Maps RNA-protein interactions under cellular stress

Labs & Teams: The Guttman Lab fosters an inclusive environment for students and postdocs, emphasizing innovation and cross-disciplinary collaboration. Recent lab members include Paulomi Bhattacharya, Andrew Perez, and Jimmy Guo, who have contributed to high-impact studies on nuclear organization and RNA biology.