Mike Dekker

Mike Dekker is a Researcher in the Pharmacy department at the Faculty of Medicine, Erasmus University Rotterdam (Erasmus MC). His scientific work focuses on molecular mechanisms of stem cell regulation, with particular expertise in transcriptional control systems governing neural and hematopoietic development.

His primary research interests include:

• Stem Cell biology and differentiation pathways
• Gene Control mechanisms and regulatory networks
• E2F transcription factor functions
• CHD8 protein roles in development
• Transcriptional regulation in neural systems
• Chromatin organization and locus control regions

Dr. Dekker's research bridges molecular biology with medical applications, particularly in understanding developmental disorders and cancer pathways through the lens of stem cell regulation. His work often involves sophisticated protein interaction analyses and transcriptional profiling to uncover how chromatin regulators influence cell fate decisions.

Analysis of his publication record reveals a consistent focus on transcriptional regulation in stem cell systems. His most recent work examines the CHD8-TRRAP axis in MYC and E2F target gene regulation (2025), building on earlier research into Mediator complex interactions (2019) and CBX7-mediated stem cell self-renewal mechanisms. This trajectory shows an evolving expertise in chromatin regulation and its implications for both normal development and disease states, with particular relevance to neurodevelopmental disorders and hematopoietic malignancies.