Michele Di Pierro

Michele Di Pierro is an Assistant Professor in the Department of Physics at Northeastern University’s College of Science. He leads the Di Pierro Lab, which investigates physical genetics by exploring how genetic information is physically translated and organized through statistical physics, information theory, and computational modeling. His research focuses on genome architecture, chromatin dynamics, and nuclear organization, with notable work on ancient genome preservation in a 52,000-year-old woolly mammoth sample.

Key research themes include energy landscapes of chromosome structures, phase-separated chromatin compartments, and mesoscale modeling of nuclear organization. His lab develops computational tools like the Nucleome Data Bank to simulate genome structures. Di Pierro collaborates across disciplines to bridge physics and molecular biology, advancing both theoretical understanding and biotechnological applications.

He is affiliated with Northeastern’s Department of Physics and contributes to interdisciplinary research within the College of Science. His work addresses fundamental questions about how physical principles govern genetic processes at molecular scales.