Michael T. Hemann

Michael T. Hemann is a Professor of Biology at the Massachusetts Institute of Technology (MIT), affiliated with the Koch Institute for Integrative Cancer Research. His research focuses on understanding mechanisms of chemotherapy resistance and developing strategies to enhance cancer therapies through genetic and functional screening approaches.

Education:

• PhD, 2001, Johns Hopkins University
• BS, 1993, Molecular Biology and Biochemistry, Wesleyan University

Research Interests: His lab employs mouse models and high-throughput screening to investigate drug resistance mechanisms in cancers. Key areas include:

• Genetic basis of chemotherapy resistance
• Identification of novel drug targets
• Development of combination therapies
• Role of tumor microenvironment in treatment response

Recent Research Trends: Publications highlight advancements in:

• CAR-T cell engineering for leukemia treatment
• CRISPR-based functional genomics approaches
• Molecular mechanisms of drug resistance
• Immune modulation in cancer therapy

Labs/Teams: Hemann leads the Hemann Lab at the Koch Institute, which integrates preclinical models and computational biology to advance translational oncology research. The lab collaborates extensively with other cancer research groups at MIT and beyond.