Michael Scheid

Michael Scheid is an Associate Professor and Associate Dean Students in the Department of Biology at York University, Faculty of Science. His research focuses on signal transduction pathways regulating cell growth, survival, and metabolism, particularly in cancer and diabetes contexts. Key areas include PI3K/AKT pathways, PDK1 regulation, and AGC kinase family dynamics. Methodologies involve molecular biology, cell biology, microscopy, and biochemical assays.

Research Interests: Dr. Scheid’s lab investigates how dysregulated signaling pathways contribute to diseases like cancer. They study PDK1’s role as a 'master switch' for AGC kinases and combinatorial drug therapies targeting multiple pathways. Recent work includes ROCK2 protein modifications, MEKK2-JNK activation, and CDCA7 phosphorylation by AKT.

Publications Summary: Key contributions span molecular mechanisms of kinase activation (e.g., PKB/AKT, ROCK2), protein interactions (e.g., MEKK2-14-3-3), and cancer-related signaling (e.g., MYC regulation). Over 20 peer-reviewed articles since 1999 highlight his work in Biochem J, Mol Cell Biol, and J Biol Chem.