معرفی
Michael Mather, PhD, is a Research Associate Professor in the Department of Microbiology & Immunology at Drexel University College of Medicine. His work focuses on the physiology of malaria parasites, particularly mitochondrial functions and energy metabolism, with an emphasis on identifying novel drug targets and understanding resistance mechanisms. He collaborates with the Center for Molecular Parasitology under Prof. Akhil Vaidya.
Education: PhD from the University of Illinois (1984). His research includes studies on mitochondrial proteomics, ELQ drug candidates (e.g., ELQ-300), and functional genomics of Plasmodium species. He investigates mechanisms underlying drug resistance to antimalarials like atovaquone and explores synergistic drug combinations.
Key research areas include mitochondrial electron transport, heme biosynthesis, and TCA cycle pathways, with a focus on their roles in parasite survival. His lab uses techniques such as BioID proximity labeling and genetic ablation to study mitochondrial components. Collaborations include NIH, Medicines for Malaria Venture, and the Wellcome Trust Sanger Institute.
Publications span over two decades, emphasizing mitochondrial drug targets, antimalarial drug development, and parasite metabolism. His work contributes to understanding minimalistic metabolic strategies of Plasmodium and developing affordable, long-acting treatments.
