معرفی
Manuel Llinás is the Ernest C. Pollard Professor in Biotechnology and Professor of Biochemistry and Molecular Biology and Chemistry at The Pennsylvania State University. His research focuses on understanding the molecular mechanisms of gene regulation and metabolism in the malaria parasite Plasmodium falciparum using functional genomics and metabolomics. Key areas include transcriptional regulation via ApiAP2 proteins and Plasmodium metabolomics to identify drug targets.
- Affiliations: Center for Eukaryotic Gene Regulation, Center for Infectious Disease Dynamics, Center for Malaria Research.
- Research Interests: Gene regulation, parasite metabolism, antimalarial drug discovery.
His lab combines functional genomics, molecular biology, and metabolomics to study Plasmodium's developmental stages (blood, liver, mosquito). Recent work highlights chromatin remodeling factors (e.g., Snf2L) and ApiAP2 proteins as critical regulators. Metabolomic studies revealed unique metabolic pathways, including acetyl-CoA biosynthesis and red blood cell interactions.
Publications emphasize multistage antimalarial compounds targeting ApiAP2 proteins and metabolic vulnerabilities. Awards include AAAS and ASTMH Fellowships and the Penn State Faculty Scholar Medal.
Lab activities involve training graduate students (e.g., Alan Brown, Emma Hutchinson) and leveraging metabolomics and CRISPR tools. Current projects focus on drug targets in transcriptional networks and metabolic pathways.
