Michael James Burke

Dr. Michael James Burke is Professor of Pediatrics at the Medical College of Wisconsin, where he holds multiple leadership roles including Leukemia & Lymphoma Program Director and Director of Translational & Clinical Research. His primary affiliations include the Children's Hospital of Wisconsin and Froedtert Memorial Lutheran Hospital, with prior academic appointments at the University of Minnesota.

His research focuses on pediatric hematologic malignancies, particularly acute lymphoblastic leukemia (ALL), where he investigates:

• Novel therapeutic approaches for relapsed/refractory disease
• Genomic determinants of treatment response
• Epigenetic modulators and immunotherapy
• Bone marrow transplantation outcomes
• Targeted drug delivery systems

Analysis of his 15 most recent publications reveals strong emphasis on precision oncology strategies, including genomic risk stratification, biomarker-driven therapies (e.g., PDGFRA inhibition), and optimization of chemotherapy agents like asparaginase and carfilzomib. Recurrent themes include CNS involvement prognostication, management of treatment toxicities, and special population considerations (Down syndrome).

Notable scientific awards include:

• Best Doctors in America (2009-Present)
• Milwaukee Magazine Top Doctors (2015-Present)
• Magna Cum Laude, Ross University
• Zabish Memorial Scholarship

He actively leads NIH-funded clinical trials through COG and TACL consortia, with grants totaling millions from NCI, St. Baldrick's Foundation, and industry partners. As former Fellowship Director at University of Minnesota, he mentors trainees in translational research methodologies.

Dr. Burke oversees developmental therapeutics initiatives and coordinates multicenter research networks investigating epigenetic reprogramming, cellular therapies, and leukemia genomics.