Zachary T. Graff

Zachary T. Graff, MD is an Assistant Professor in the Department of Pediatrics at the Medical College of Wisconsin, specializing in Hematology, Oncology, and Bone Marrow Transplantation. He holds leadership roles including Director of Medical Education for the division and serves as Institutional PI for the Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) consortium.

His research focuses on pediatric leukemia therapeutics with emphasis on:

• Immunotherapy development (FLT3 CAR T-cells)
• Epigenetic modulation in AML
• Global oncology initiatives (retinoblastoma protocols in Guatemala)
• Novel targeted therapies for relapsed/refractory malignancies

Recent publications demonstrate strong focus on leukemia biology and clinical trial development, with 6 oncology articles published since 2023 predominantly in high-impact hematology/oncology journals. Research consistently addresses immunotherapy mechanisms and treatment optimization for high-risk pediatric cancers.

Awards and honors:

• Conroy Family Young Investigator Award (2019)
• MCW Outstanding Medical Student Teacher (2021-2022)
• Alpha Omega Honor Society (2014)
• AACR/ASCO Methods in Clinical Cancer Research Workshop (2020)

Active in mentoring medical students and fellows, with current advisees including Lauren Kacvinsky (hematology research) and Elizabeth Alessio (clinical shadowing). Leads multiple clinical trials including a phase I study of venetoclax combination therapy for relapsed pediatric AML funded by institutional grants.