معرفی
Michael Cahalan is a Professor and Chair of Physiology & Biophysics at the University of California, Irvine School of Medicine. His research focuses on ion channel physiology, calcium signaling, and their roles in immune cell function, neurodevelopment, and neurodegenerative diseases. Key areas include mechanotransduction in macrophages, microglia biology in Alzheimer’s disease, and the regulation of T cell signaling through CRAC channels. Dr. Cahalan has contributed to understanding how calcium dynamics influence immune responses and stress circuit development. His work spans experimental techniques such as calcium imaging, genetic models, and in vivo imaging of immune cell behavior.
Research Interests: Cell signaling pathways, immunology, ion channel function in T cells and microglia, calcium-dependent mechanisms in neuroinflammation, and the impact of early-life adversity on stress circuitry. His studies often integrate biophysical approaches with genetic and pharmacological tools to dissect cellular mechanisms.
Grants & Funding: Supported by NIH grants including GM-41514 and NS-14609, focusing on ion channel biology and neuroimmune interactions.
Labs & Teams: Leads a lab investigating immune cell calcium signaling and microglial function in neurodegenerative diseases. Collaborates on projects involving human iPSC-derived microglia models and in vivo imaging of spinal cord dynamics.
