Michael B. Boffa

Dr. Michael B. Boffa is an Associate Professor in the Department of Biochemistry at Western University, where he investigates the multifunctional TAFI protein and its role in cardiovascular disease. His research spans:

• Protein Biochemistry: Structural instability of TAFIa, molecular mechanisms of activation
• Cardiovascular Research: Atherosclerosis progression, thrombosis, sex-specific plaque vulnerability
• Cancer Biology: TAFI's inhibitory effects on breast cancer metastasis
• Lipid Metabolism: Molecular regulation of lipoprotein(a), receptor identification challenges

Key article trends (2017-2025) focus on Lp(a)-targeted therapies, transgenic disease models, and clinical lipidology translation. Current research explores:

• Protein structure-function relationships
• Sex-specific cardiovascular mechanisms
• Novel therapeutic targets for Lp(a) regulation
• Translational applications in preventive cardiology