معرفی
Michael Aschner, Ph.D., is a Professor in the Department of Molecular Pharmacology, Dominick P. Purpura Department of Neuroscience, and Department of Pediatrics at Albert Einstein College of Medicine. He holds the Harold & Muriel Block Chair in Molecular Pharmacology and directs the Einstein Center of Toxicology. His research focuses on metal-induced neurotoxicity mechanisms, particularly mercury and manganese, and their interactions with genetic factors and dopamine signaling. He investigates environmental triggers of neurodegeneration using models ranging from C. elegans to human MRI studies. Key areas include oxidative stress pathways, Parkinson’s disease risk factors, and developing improved disease models through environmental science insights.
Research highlights include studying Nrf2’s role in combating methylmercury-induced injury and exploring how PARK2 genetic variants influence manganese toxicity. His work aims to identify therapeutic targets for neurodegenerative disorders and understand metal deposition impacts in neonatal brains. Aschner’s lab employs cutting-edge techniques like single-cell RNA sequencing to analyze methylmercury effects on neurodevelopmental processes.
Professional affiliations include leadership roles at Einstein College of Medicine and Montefiore Health System. His contributions bridge environmental toxicology with clinical neurology, focusing on translating basic science findings into clinical applications for neurodegenerative diseases.
