معرفی
Dr. Douglas Lobner is a Research Professor in the Department of Biomedical Sciences at Marquette University, College of Health Sciences. His research focuses on neurodegenerative disease mechanisms, environmental toxin interactions, and dental material toxicity. He investigates how environmental factors like mercury, pesticides, and BMAA interact with genetic predispositions to cause neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS, particularly through the cystine/glutamate transporter (system xc-).
His work also explores dental pulp capping materials, emphasizing growth factor-enhanced repair mechanisms and system xc- regulation to prevent root canal procedures. Key collaborations involve studies on glutamate signaling, neurotoxicant synergy, and drug-induced neuroplasticity.
Published research includes over 14 studies from 2009–2014, emphasizing system xc- regulation by growth factors, neurotoxin synergies (e.g., methylmercury and BMAA), and dental material toxicity mitigation strategies. His lab contributes to the Neuroscience Collaboratory and Integrative Neuroscience Research Center at Marquette.
