معرفی
Melanie Cobb is a Professor in the Department of Pharmacology at the University of Texas Southwestern Medical Center, holding the Jane and Bill Browning, Jr. Chair in Medical Science. Her research focuses on cellular regulatory mechanisms, particularly protein kinase signaling pathways such as ERK1/2 MAP kinases and WNK kinases. Her work spans pancreatic β-cell function, cancer biology (including small cell lung cancer), and hypertension-related mechanisms. She leads the Cobb Laboratory, investigating how cells respond to hormonal, nutrient, stress, and developmental signals.
Education
- Bachelor’s in Biochemistry, University of Chicago
- PhD in Biological Chemistry, Washington University in St. Louis (lab of Garland Marshall)
- Postdoctoral work with Ora Rosen at Albert Einstein College of Medicine
Research Highlights
Dr. Cobb’s lab explores:
- ERK1/2 roles in nutrient-sensing pathways, particularly in pancreatic β-cells and cancers (e.g., SCLC)
- WNK1 kinase’s effects on ion channels, endothelial cell migration, and hypertension pathogenesis
- Mechanisms linking insulin gene transcription to ERK signaling and calcineurin
Awards & Recognition
No awards explicitly listed in provided texts.
Lab & Collaborations
The Cobb Laboratory collaborates on projects involving kinase regulation, cancer biology, and metabolic disorders. Opportunities exist for students and researchers to join the team through open positions.
